The present study was designed to learn the effect of oxidative stress in patients registered with heart diseases by conducting some tests and measurements of some enzymes such as: aspartate aminotransferase (AST) concentration, Creatine phosphokinase (CPK),. (85) blood samples were selected from (60 male and female patients and 15 healthy individuals). The samples were divided into four groups: The first group: included patients with myocardial infarction, numbering (30) patients (males and females), whose ages ranged between (35 - 89) years. The second group: included patients with angina pectoris, numbering (20) patients (males and females), whose ages ranged between (32 - 85) years. Control group: This group included (15) individuals (males and females), ranging in age from (30-57) years. The current study showed the following results: There was a significant increase at a significance level (p<0.05) in the concentration of aspartate aminotransferase (AST) in the angina group in males and in the heart failure group in females, and in these two groups within the group (males + females), male gender, diabetics and smokers. A significant increase at a significance level (p<0.05) in the concentration of the enzyme creatine phosphokinase (CPK) in patients with myocardial infarction, males and females (males + females), male gender, age group (80-89 years), patients with high blood pressure, diabetes and smokers.