Introduction: Laryngoscopy and tracheal intubation is a noxious stimulus, leading to a marked sympathetic response. Patients with cardiovascular or cerebral disease are at increased risk. Various drugs and laryngoscopy methods are used to effectively attenuate this response. The aim of the study was comparing the clinical efficiency in attenuation of hemodynamic response provided by Tab pregabalin 200mg given 2 hours pre-emptively with that of IV lignocaine given 90 seconds prior to intubation and to study the side effects of the drug if any.  Materials and Methods: After Ethical Committee Clearence from the institute and written informed consent. 30 patients, aged 18–60years, ASA grade I and II, of both genders were randomized into two groups of 15 each. Group I received Tab pregabalin 200mg 2 hours prior to surgery, Group II received Inj lignocaine 1.5mg/kg IV 90 seconds prior to intubation. Anaesthetic technique was standardized to both the groups. The statistical software namely SPSS 22.0, and R environment ver.3.2.2 were used for the analysis of the data and Microsoft word and Excel have been used to generate graphs, tables etc. Hemodynamic parameters were observed at baseline, pre-induction and 1,2,4,6,8,10 and 15 minutes after laryngoscopy and intubation along with sedation score and post-operative side effects. Results: The mean basal and pre-induction heart rate, systolic, diastolic and mean arterial pressure was comparable between 2 groups (p-value >0.05). The patients had significant attenuation in heart rate with (p-value <0.05) at 1,2,4,6, and (p-value <0.01) at 8,10,15 minutes in pregabalin group compared to lignocaine group, systolic, diastolic and mean arterial pressures were too significantly lower at 1,2,4,6,8,10 and 15minutes in pregabalin group. Conclusion: Pregabalin 200mg as premedication is more effective in attenuating hemodynamic response to laryngoscopy compared to IV lignocaine with no significant side effects.