Forty patients from Baghdad Hospital were collected for the results used in this study. The research aims to determine where the effects of anesthesia on heart disease were identified, and all results were recorded. In addition to that, a statistical analysis was conducted, and the average age of the participants was from 40 to 65 years. The primary task of administering anesthesia for myocardial revascularization in a beating heart is the prevention of myocardial ischemia. Over the past years, the possibility of using epidural anesthesia (EA) in cardiac surgery has been discussed, which can solve a number of the above problems. Actively. This is primarily associated with the emergence of new, low-toxicity local anesthetics, particularly ropivacaine, and the improvement of technical capabilities of puncture and catheterization of the epidural space. At the same time, the combined method, which combines general anesthesia with upper thoracic EA, which allows avoiding attacks of myocardial ischemia more effectively, received well-deserved recognition. To prevent the development of the body's stress response to an operating injury and to provide high-quality anesthesia after surgery. However, EA in open-heart surgery can be associated with several risks and complications.