Background: Cisplatin is a potent chemotherapeutic agent, but its clinical utility is often limited by nephrotoxicity and systemic inflammation. The current study aimed to investigate the protective effects of Ginger (Zingiber officinale) against cisplatin-induced acute kidney injury in a rat model. Materials and methods: Forty-eight male rats were divided into six groups: control, cisplatin-only, and Cisplatin co-administered with low, moderate, or high doses of Ginger alongside a ginger-only group. Results: Biomarker analysis revealed that Cisplatin significantly elevated urea, creatinine, TNF-α, IL-6, Caspase-9, and MDA, indicating renal dysfunction, oxidative stress, and inflammation. Co-treatment with Ginger reduced these markers in a dose-dependent manner, with high-dose Ginger (1000 mg/kg) demonstrating the most significant nephroprotective effects, restoring biomarkers near control levels. Histopathological analysis further supported these findings, showing reduced kidney tissue damage and enhanced cellular regeneration in ginger-treated groups. Conclusion: These results suggest that Ginger, particularly at higher doses, may serve as a safe and effective adjunct therapy for mitigating cisplatin-induced nephrotoxicity by modulating inflammation and oxidative stress.