srjcmsSRJCMSSRJCMS2788-885110.47310/srjcms.2025.v05i01.001Ginger Utilizing as a Co-factor in Attenuating the Nephrotoxicity Caused by Cisplatin as Tumour Chemotherapy TreatmentDina A.A. AbdullahHamid K.Al-TameemiShahrazadAhmedKhalafDepartment of Science, College of Basic Education, University of Diyala, Baqubah, IraqCollege of Medical and Health Techniques, University of Bilad Alrafidain, Diyala, Iraq.Department of Forensic Science, College of Science, Diyala University,Background: Cisplatin is a potent chemotherapeutic agent, but its clinical utility is often limited by nephrotoxicity and systemic inflammation. The current study aimed to investigate the protective effects of Ginger (Zingiber officinale) against cisplatin-induced acute kidney injury in a rat model. Materials and methods: Forty-eight male rats were divided into six groups: control, cisplatin-only, and Cisplatin co-administered with low, moderate, or high doses of Ginger alongside a ginger-only group. Results: Biomarker analysis revealed that Cisplatin significantly elevated urea, creatinine, TNF-α, IL-6, Caspase-9, and MDA, indicating renal dysfunction, oxidative stress, and inflammation. Co-treatment with Ginger reduced these markers in a dose-dependent manner, with high-dose Ginger (1000 mg/kg) demonstrating the most significant nephroprotective effects, restoring biomarkers near control levels. Histopathological analysis further supported these findings, showing reduced kidney tissue damage and enhanced cellular regeneration in ginger-treated groups. Conclusion: These results suggest that Ginger, particularly at higher doses, may serve as a safe and effective adjunct therapy for mitigating cisplatin-induced nephrotoxicity by modulating inflammation and oxidative stress.