Research was conducted to observe the influence of the information system at Harapan Bersama Singkawang Hospital (RSUHB). The population in this study are RSUHB outpatients, in total 90 respondents. This research uses a Structural Equation Model (SEM) approach with a measurement model using the SmartPLS version 3.2.9 program to measure the intensity of each research variable and a structural model to analyze data and research hypotheses. The results obtained shows that the management information system has a significant effect on patient satisfaction, the management information system has a significant effect on patient loyalty, patient satisfaction has a significant effect on patient loyalty, and finally the management information system has a significant effect on patient loyalty. patient satisfaction is mediated by patient satisfaction.