In addition to polymerization of Heamoglobin S in red blood cells under deoxygenated conditions, recent studies have demonstrated that an imbalance in the oxidant – antioxidant system is also involved in the pathophysiology of sickle cell disease. This oxidative stress plays a very critical role in the symptoms and complications of sickle cell disease and conventional therapies directed to restore this balance have proved beneficial. Extracts of the leaves of Terminalia catappa L. which have been shown by recent researchers to have antisickling activity were investigated for its ability to restore the oxidant – antioxidant balance in this study. The ability of the n-Hexane and ethanol extracts of T. catappa leaves to restore nitric oxide availability under physiological conditions was assessed using the Griess reaction assay and results show that only higher concentrations (≥600 µg/ml) of the ethanol extracts exhibited nitric oxide generating activity. Standard Fe²⁺ Chelation Assay was used to evaluate the ability of the extracts to reduce Iron overload under physiological conditions and only the n-Hexane extract was able to chelate free iron.