Aim: The aim of this study is to evaluate the utilization of diabetic ulcer severity score as predictor of amputation. Objective: The objective of this study is to co-relate the diabetic ulcer severity score with the clinical outcome and evaluate the diabetic ulcer severity score as predictor of amputation. Materials and Methods: The study was conducted on 100 patients with foot ulcer and suffering from diabetes mellitus (as per WHO criteria) DUSS was calculated and patients received routine medical care for blood sugar control and wound care with debridement and wound dressing and final outcome co-related with the total DUSS. Results were analyzed and efficacy of DUSS to predict amputation in diabetic ulcers patients calculated. Results: Out of 100 patients, 29% of patients had major amputation, while 25% of them underwent minor amputations, 24% and 22% of ulcers healed by primary intention and split skin graft respectively. The probability of amputation with score of 0 was 5%, with score 1 was 12%, with score 2 was 27.28%, with score 3 was 47.06% and with score 4 was 68.75%. Discussion: Overall, 54 of 100 people had amputations in our study. Major amputation (below or above knee amputation) was done for 29% of patients in our study. Minor Amputation (toe or forefoot amputations) was done in 25% of patients in our study. 1 out of 20 with score 0, 3 out of 25 with score 1, 6 out of 22 with score 2, 8 out of 17 people with score 3 and 11 out of 16 people with score 4 had major amputations. Conclusion: Diabetic Ulcer Severity Score is easily applicable cost and time efficient scoring system to predict the clinical outcome in diabetic patients having foot ulcer without altering the routine line of management. Higher the total DUSS higher the risk of major amputation in diabetic patients with foot ulcer.