A number of obstacles hamper drug delivery to specific locations. Tablets, capsules, suspensions, emulsions, elixirs, lotions, etc. have limited bioavailability, shelf life, drug-excipient incompatibility and patient noncompliance. Thus, nanoparticles are now proven to be a preferable option due to the development of innovative drug delivery methods like liposomes. In 2011, Spanlastics, a new approach with fewer side effects, was released as part of the advancement of the drug delivery system. They utilize their bilayer, which supports the release of encased drugs, to release medication in a controlled manner, also deformable nanovesicles made of surfactants that surround an aqueous solute solution. There is evidence that they are more stable chemically. They offer targeted delivery and regulated release of natural medicinal substances and improve the availability of the drug at the location. They have addressed a number of shortcomings of the traditional dosage form. The purpose of this review is to highlight the application of plastics, the penetration mechanism, various preparation methods and their evaluation criteria.