OBJECTIVE: Septic shock is a state of extreme physiologic stress associated with a wide array of hemodynamic, metabolic and physiologic processes attempting to restore homeostasis Clinical guidelines recommend norepinephrine as initial vasopressor of choice for septic shock, with dopamine suggested as an alternative vasopressor in selected patients with low risk of tachyarrhythmias and absolute or relative bradycardia. Patients with septic shock treated during shortage of norepinephrine, the recommended first line, were more likely to die and based on this critical issue we aim in this study to evaluate the clinical effectiveness of ino-constrictor dose of dopamine as an alternative vasopressor during norepinephrine shortage regarding the percentage changes in mean arterial pressure (% ∆MAP), risk of tachyarrhythmia,  ICU length of stay (LOS) and 28-day ICU mortality. MATERIALS and METHODS: A retrospective analysis will be conducted in our adult ICU at King Hussein Medical Hospital (KHMH) for patients who were admitted via the emergency department (ED) or via other hospital wards between April 2018 and April 2020 and who were their baseline demographics, diagnostics, anthropometrics, hemodynamics, fluids and vasopressors can be obtained or assessed from our institutional electronic health record (Hakeem). Patients will be excluded if they discharged or died before completed at least 1 week of ICU admission. A chi square test will be conducted to evaluate the proportion of studied patients in both tested vasopressors who had HR >120 bpm and overall, 28-day ICU mortality. An independent T-test will be conducted to compare the Mean±SD and Mean difference±SEM of %∆MAP and ICU LOS between the two tested vasopressor groups. RESULTS: Dopamine associated with significant increases in the Means±SDs of: SBPavg (101.87±10.00mmHg vs. 94.33±9.17mmHg); DBPavg (60.12±7.32mmHg vs. 55.67±7.01 mmHg); and MAPavg (71.31±11.69mmHg vs. 66.53±10.84 mmHg). And a significant reduction in HRavg (95.13±8.7bpm vs. 107.31±9.35bpm); SIavg (1.39±0.38 bpm/mmHg vs. 1.68±0.47 bpm/mmHg); and mSIavg (1.39±0.38 bpm/mmHg vs. 1.68±0.47 bpm/mmHg) compared to Norepinephrine. CONCLUSION: Dopamine is associated higher mortality and a higher incidence tachyarrythmia compared to norepinephrine.