Fostering entrepreneurship among youth is critical to achieving the goal of the Vietnamese Government as having one million businesses operating effectively until 2020. This requires an understanding of entrepreneurial intentions in this population as well as related potential barriers and facilitators. However, evidence of entrepreneurial intentions in Vietnamese youth is limited. This paper aims to clarify the factors that affect entrepreneurial intentions among Millennials in Ho Chi Minh City, Viet Nam. This paper examined the effect of the set of five factors on Entrepreneurship Intention of Millennials. The data was gathered from 310 young people aged from 18 to 40 years old in Ho Chi Minh city. This paper applied both qualitative and quantitative approach with statistical technique as SPSS. As a result, Entrepreneurial Attitude factor had the most influence on Entrepreneurial Intention among Millennials in Ho Chi Minh, followed by Perceived Desirability and Perceived Feasibility, and the least influential factor is Entrepreneurial Knowledge. On the contrary, Social Norm factor does not pose a direct impact on the entrepreneurship intention among youth in Ho Chi Minh City, Viet Nam.