srjalsSRJALSSRJALS2788-9386https://doi.org/10.47310/srjals.2021.v01i01.006The Effect of the Drug Ivermectin (Mectizan) On the In Vitro Inhibition of Bacteria GrowthK.JAlagoaJ.EOziDepartment of Biological Sciences, Faculty of Science, Niger Delta University, Amassoma, Bayelsa State, NigeriaThe effect of the Mectizan on the inhibition of bacterial growth was investigated. This was done in order to test the potency of this drug on bacteria growth due to its touted potency in the prevention of the replication of the SARS-CoV-2 virus that causes the COVID -19 and the possible use of this drug in antibiotic resistant bacteria. Clinical identified Oral bacteria, Staphylococcus aureus, Bacillus cereus, Citrobacter freundi and Enterobacter sp. were obtained from a preserved culture obtained from a recent work carried out in the Biological laboratory, faculty of sciences, Niger Delta University, Bayelsa State. The tested drugs Mectizan (Ivermectin) and Ampiclox (a positive control) were both gotten from a pharmaceutical store for the susceptibility test. The drug dose difference (3-9mg) as recommended per patients was not exceeded. Thus; 3mg/mL, 6mg/mL and 9mg/mL of Mectizan was impregnated on the tested organism and compared with the standard prescribed dose concentration of the positive control (500mg). The dose difference was tested with each of the oral pathogens: Staphylococcus aureus, Bacillus cereus, Citrobacter freudi and Enterobacter sp. The bacteria were stained with Ampiclox antibiotic and the zones of inhibition were measured after 24 hours of staining. Result of the investigation reveal that there was a significant difference (p<0.05) between the control (Ampiclox 500mg) and all dosage ranges of mectizan in bacteria inhibition of all the tested bacteria. There was no significant difference (p>0.05) in inhibition of bacteria growth with all doses of Mectizan on all bacteria types. However, higher inhibition rates were observed with increased drug doses. Mectizan had a higher inhibition on gram negative bacteria (Citrobacter freudi and Enterobacter sp) than gram positive bacteria (Staphylococcus aureus, Bacillus cereus) whereas Ampiclox had a higher effect on gram positive bacteria than gram negative bacteria. It can be concluded that Mectizan shows great promise either as an adjunct or replacement to antibiotics in the treatment of bacteria pathogen especially with increased dosage and sustained use.