iarjcrIARJCRIARJCR2789-6064https://doi.org/10.47310/iarjcr.2022.v02i02.015Triazole-Scaffold: An Efficient Sensor for Trace Iron Ion Detection and Cellular Imaging Application – A ReviewSalahuddinSyedChemistry Section, School of Sciences, Maulana Azad National Urdu University, Hyderabad, IndiaThe triazole-scaffold plays a crucial role as a specific and selective detection of Fe3+ ion in biological and environmental systems. These probes provide an efficient molecular platform for sensing of Fe3+ ion at ultra-low concentrations and bio-imaging applications. The N-rich triazole ring facilitate strong metal-ligand complexation and induces photo-induced electron transfer (PET)-based fluorescence quenching upon Fe3+ binding. The spectroscopic analyses (UV-vis absorption, fluorescence emission) revealed the 1:1 stoichiometry ratio and complex formation followed by distinct “turn-Off” and “turn-On” response, as well as bathochromic and hypsochromic shifts indicative of charge transfer effect. These probes exhibit ultralow detection limits, high selectivity, excellent cell permeability and good biocompatibility enabling real-time Fe3+ visualization. Overall, this review highlights that trizaole-scaffold-based sensor provide a versatile, cost-effective and reliable platform for environmental and biomedical applications.