srjmsSRJMSSRJMS2788-9483https://doi.org/10.47310/srjms.2025.v05i02.002Histopathological and Hormonal Effects by Some Athletic Supplements used in Iraqi Gyms on Reproductive System of Male Albino RatsWalaaA. AbdulridhaIshtarAdnan Alethari2Department of Environment, College of Sciences, University of Al-Qadisiyah, IraqCollege of Veterinary Medicine, University of Al-Qadisiyah, IraqThere are several reasons behind men infertility, bad nutrition or some diseases either physiological or bacterial causes may be affecting sexual system or its accessories. The present study mimic state of male individuals having athletic supplements without training. This is through evaluating the effect of the most famous supplements in Iraqi gyms on histological architecture and functions of reproductive organs by means of hormones in males of albino rats. Three types of supplements were chosen for the experiment: Isotpe with proteinic nature, Crea Pro with creatine nature and Al-mass with carbohydratic nature. Twenty male rats were divided into four groups (n = 6):normal group (C) of control animals supplemented with normal feed and distailed water, group (G1) where animals dranched concentration (o.627) gm/mL of al-mass, group (G2) where animals dranched Crea Pro with concentration (0.7) gm/mL, group (G3) where animals dranched isotopic supplements with concentration (0.636) gm/mL. The treatments were continued for 30 days consecutively. In comparsion to control group, the results of biochemical test shows that Testosterone hormone in G3 has decreased to 4.93±2.88 IU.L, while G1 and G3 have the highest values with 5.89±4.59 IU/L. Leutenizing Hormone (LH) has increased non-significantly to 2.30±0.70 IU/L in G2 in comparssion to other groups, while G1 has the lowest value by 1.20±0.17 IU/L. Values of follicle stimulated hormone (FSH) also affected non-significantly by supplements. All the treatment has an increasing in FSH value in serum in comparssion to control. Histopathological horizantal sections of epididymis, seminal vesicles and testis were examined. Sections of epididymis show that all the treatment groups are effected by few stereocilli, lumen empty from sperms, hemorrage among epididymal lobules. Seminal vesicles show changes in G1, G2 and G3 but with different degrees. The changes involve thickness of smooth muscle, few or zero lubricating fluid, thick stratified epithelial tissue, in addition to necrotic area in some sections. Testis also is affected by treatment groups. Seminferous tubules are found with different diameter, the lumen has few or zero spermatozoa, loss of germ cells, vaculation among spermatids.