iarjaccIARJACCIARJACC2709-188010.47310/iarjacc.2024.v05.i02.004Effect of Intratracheal Dexmedetomidine Combined with 4% Lignocaine before Intubation on Hemodynamic Changes During Intubation in Head Injury PatientsRamPrakashGangwarRatanPalSinghRangitPriyakarPandeyShaheenBegumJunior resident, Department of Anaesthesiology ,RMRI Bareilly Uttar Pradesh.Professor, Department of Anaesthesiology ,RMRI Bareilly Uttar Pradesh.Professor and Head Department of Anaesthesiology,RMRI Bareilly Uttar Pradesh.Senior Resident Department of Anaesthesiology ,RMRI Bareilly Uttar PradeshIntroduction: hemodynamic changes during tracheal intubation it is more challenging in head injury patients . Dexmedetomidine is a selective α2 adrenoreceptor agonist used as a sedative and adjuvant with local anesthetic. We hypothesized that adding dexmedetomidine to lignocaine before intubation have positive outcome on hemodynamic changes. Aim and objective: To assess the effect of Intratracheal Dexmedetomidine with lignocaine on hemodynamic changes during intubation in head injury patient .Methodology: Sixty patients admitted in ICU with head injury and need intubation randomly divided into two groups 30 subjects in each group, namely, Group 1 and Group 2. Group 1 received dexmedetomidine 0.5 ml with 4% lignocaine 0.5 ml whereas Group 2 receive normal saline before endotracheal intubation, respectively. The outcomes were the incidence hemodynamic fluctuations during intubation and after intubation .Results: The incidence and severity of hemodynamic fluctuation in Group 1 than in the group 2, during intubation and post intubation is significantly lower . Moreover, compared with Group 2, Group 1 exhibited more stable haemodynamics during intubation as well as post intubation .Conclusion: The combined use of dexmedetomidine and lignocaine intratracheally before intubation significantly reduced the incidence and severity of haemodynamic fluctuations during and after intubation.