2026-Zeeshan-1 20240803000000 iarcin:iarcin m.arslansohail@gmail.com IARCON INTERNATIONAL LLP Scientific Research Journal of Pharmacy Sci. Res. J. Pharm. 2788-9564 10.47310/srjp https://www.iarconsortium.org/srjp/ 08 03 2024 08 03 2024 4 1 10.47310/srjp.2024.v04i01 https://www.iarconsortium.org/srjp/archives/57/242/ Modification of Amoxicillin antibacterial to promising anticancer azomethine derivatives: Synthesis and in vitro studies Zuhoor Abdl Latef Thame Roaa Jawad Jaber The present study provides an original way for synthesizing imines (A and B) by reacting amoxicillin with 2,4-dihydroxybenzaldehyde and 4-methylbenzaldehyde. The derivatives (A and B) were analyzed using FT-IR Spectroscopy. Using the zone inhibition method, the in vitro evaluation of synthesized derivatives (A and B) was conducted against several bacteria, including Streptococcus pneumonia and E. coli. The results indicated that specific derivatives possess enhanced antibacterial capabilities compared to the effectiveness of regular medication. The derivative A was assessed for its anticancer activity against prostate cancer PC3 cells using the MTT assay, which yielded a favorable outcome within 48 hours. 08 03 2024 08 03 2024 1 5 10.47310/srjp.2024.v04i01.003 https://www.iarconsortium.org/srjp/57/242/modification-of-amoxicillin-antibacterial-to-promising-anticancer-azomethine-derivatives-synthesis-and-in-vitro-studies-4533/