ISRA202602 -00011130000000 iarcin:iarcin m.arslansohail@gmail.com IARCON INTERNATIONAL LLP IAR Journal of Medical Sciences IAR J. Med. Sci. 2708-3594 10.47310/iarjms https://www.iarconsortium.org/iarjms/ 11 25 2020 11 30 -0001 1 2 10.47310/iarjms.2020.v01i02 https://www.iarconsortium.org/iarjms/archives/161/2787/ Is the “unexpected” in SUDEP expectable? Finsterer J Scorza FA Scorza CA Fiorini AC We reviewed the article by [1] which presented a retrospective study of 220 patients with sudden unexpected death in epilepsy (SUDEP) from the North American SUDEP Registry (NASR), concluding that closer collaboration between death investigators and epilepsy communities is necessary to enhance the understanding of SUDEP. While the study is valuable, we raise concerns about the lack of brain autopsy data, which may miss alternative causes of death like ischemic stroke or intracerebral bleeding. Additionally, the absence of family history collection limits the identification of hereditary disorders. Another shortcoming is the lack of consideration of brain-heart connections, such as Takotsubo syndrome (TTS) and neurogenic pulmonary edema (NPE), which may contribute to SUDEP. We suggest comprehensive brain autopsy, detailed family history, and inclusion of TTS and NPE in future studies to improve the understanding of SUDEP mechanisms. 11 30 -0001 11 25 2020 1 2 10.47310/iarjms.2020.v01i02.018 https://www.iarconsortium.org/iarjms/161/2787/is-the-unexpected-in-sudep-expectable-243/