iarjcrIARJCRIARJCR2789-6064https://doi.org/10.47310/iarjcr.2021.v01i01.004Possible PHACE (PACE) Syndrome in an Adult: Case ReportCotelliMariaSofiaLavezziPatriziaTomasoniAmedeoBonettiStefanoManelliFilippoMarinellaTurlaBackground: PHACE syndrome (posterior fossa anomalies, hemangioma, arterial lesions, cardiac abnormalities/coarctation of the aorta, eye anomalies) is characterized by large infantile hemangiomas (IH) of the face, neck, and/or scalp that are associated with developmental defects. Case Presentation: We report the case of a 75 years-old caucasian man who recently received diagnosis of possible PHACE syndrome. Conclusion: We think that clinicians, especially neurologists, should consider diagnosis of PHACE syndrome when evaluating patient with cerebral and cerebellar malformations, even without cutaneous hemangioma. We also suggest that the presence of multiple cavernous manifestations should be included among PHACE diagnostic criteria, also in adult patients