iarjsIARJSIARJS2789-6102https://doi.org/10.47310/iarjs.2022.v02i02.022The Role of Nitric Oxide in Hypoxia-Induced Intraperitoneal AdhesionMadeDwianthara AgusSuetaIntraperitoneal adhesions are abnormal adhesions between tissues and organs, usually between the omentum, bowel loops and abdominal wall. One of the pathogenesis is tissue hypoxia as a result of impaired blood supply to mesothelial cells and the inflammatory process. Nitric Oxide (NO) is a pleitropic mediator of hypoxia, especially iNOS. Intraperitoneal adhesion was proposed to develop in hypoxic condition through the increasing of iNOS, which contributed directly and indirectly through reduce peristaltic in promoting intraperitoneal adhesion.