iarjimphIARJIMPHIARJIMPH2709-331Xhttps://doi.org/10.47310/iarjimph.2021.v02i02.029Effect of Lemongrass Leaf Extract (Cymbopogon Citratus) on Blood Malondialdehyde Levels of Wistar Rats after Exposure to Cigarette SmokeElisabethChindy ClaraDINyoman EhrichListerLindaChiumanBackground: Cigarette smoke would contain 1016 free radical molecules per one puff. High levels of free radical could cause oxidative stress conditions and trigger lipid peroxidation in cell membranes which would produce malondialdehyde (MDA). If the level of MDA in the blood is high, then the levels of free radicals in the body will be high. To reduce MDA levels, antioxidants are needed. One of the natural antioxidants from outside the body is lemongrass (Cymbopogon citratus). Objective: This study aimed to analyze the effect of giving lemongrass leaf extract (Cymbopogon citratus) on the blood MDA levels of rats after exposure to cigarette smoke. Methods: It was used an experimental laboratory research with Pre and Post Test Control Group Design. This study compared the results of observations in the control and treatment groups after being made treatment and it compared the levels of MDA without any treatment with levels of MDA after being given treatment. The treatment administered by giving lemongrass (Cymbopogon citratus) leaves and exposure to cigarette smoke in rats, while the output was MDA levels in rat blood. Results: The group (K+) as a positive control group had the highest mean MDA level, which was 3.3620±0.69197. The negative group (K-) with only standard feeding had lower MDA levels when compared to the positive control group (K+), which was in the range of 0.3360±0.11216. Ethanol extract of lemongrass leaves (Cymbopogon citratus) provided the benefit of reducing MDA levels when given to a group of rats exposed to cigarette smoke with a total dose (P1) of 400 mg/kg BW with an average MDA level of 0.7268±0.33445 and (P2) 600 mg /kgBB with an average MDA level of 0.2200±0.07849. Conclusion: There is a difference in blood MDA levels of Wistar rats which were given lemongrass leaf extract (Cymbopogon citratus) with those of not treated with lemongrass leaf extract (Cymbopogon citratus). Thus, there are differences in blood MDA levels of Wistar rats exposed to cigarette smoke with those of not exposed to cigarette smoke.