iarjimphIARJIMPHIARJIMPH2709-331Xhttps://doi.org/10.47310/iarjimph.2021.v02i01.011Molecular Pathogenesis of Antibody-Dependent Enhancement in Dengue Virus InfectionAnirbanKoolMousumiChakravartyUrmitaChakrabortyMoonmoonSinhaSuraiaParveenSatadalDasThe molecular mechanism of antibody-dependent enhancement in dengue virus infection is extremely complex and still, it is not clearly understood. In the past few decades, there were many cases of DHF/DSS with very high morbidity and mortality and a steady rise of new cases. Thus a clear understanding of the molecular pathogenesis of ADE is essential. In Dengue fever, DHF/DSS usually occurs by the subneutralizing or cross-reacting hetero-serotype antibodies acting on the Dengue virus. These antibodies enhance the entry of the virus via activating Fc gamma receptors FcγR. In absence of antibody, cell binding, cell entry, replication, assembly, secretion, antiviral responses are all quite different than the infection which occurs under influence of antibodies of a different serotype. In the molecular mechanism of ADE, it is important to know how interferons are suppressed and how the dual outcome of antigen-antibody reactions is important as it determines the fate of the infected person. A detailed description of all these issues is given in the manuscript.