iarjimphIARJIMPHIARJIMPH2709-331Xhttps://doi.org/10.47310/iarjimph.2020.v01i01.011Socio-demographic determinants of TB/HIV Co-infection among Patients receiving Directly Observed Treatment Short Course in an Imo State General Hospital, NigeriaObidiegwuCSChinekeHNAdoguPOUUbajakaCFBackground: Tuberculosis (TB) and Human Immunodeficiency Virus (HIV) infections continuously present as threats to health especially in sub-Saharan Africa (SSA). It is of greater good to periodically examine and evaluate the trend of TB/HIV co-infection and investigate the contributory factors in the Imo State where the magnitude of HIV and TB/HIV co-morbidity appear highly prevalent. This study was aimed at ascertaining the socio-demographic determinants of Tuberculosis and HIV Co-infection among patients who used Directly Observed Treatment Short-course (DOTS) in General Hospital Umuguma for the course of 5 years (2013-2017). Methodology: This was a descriptive, cross-sectional study which employed bivariate and multivariate logistic regression models to identify the predictors of TB/HIV co-morbidity. Statistical significance was set at p-value≤0.05. Result: Of the 2240 patients, 64% were females, 69.6%. were single while 63.9% were urban dwellers. The overall TB/HIV co-infection prevalence was 43.3%. The TB patients aged 31-40 years and 21-30 years had significantly increased odds of 55 % and 41% respectively, of having TB/HIV co-infection compared to the 1-10 years’ age group AOR = 0.32 (95% CI: 0.01-0.26) p = 0.009 and AOR = 1.41 (95% CI: 0.51-2.89) p = 0.002]. However, age groups 41-50 years and ≥60 years reduced the odds of TB/HIV co-infection among TB patients by 68% and 66% respectively compared to TB patients within the age group of 1-10 years. These were statistically significant AOR = 0.32 (95% CI: 0.01-0.26) p = 0.03 and [AOR = 0.26 (95% CI 0.01-0.26) p = 0.05. Female TB patients have a slightly reduced odds of TB/HIV co-infection at 0.9% compared to the male patients though this was not statistically significant AOR = 0.91 (95% CI: 2.15-4.66), p = 0.065. More so, residing in urban areas increased the odds of the co-morbidity by 35% of the odds of TB patients residing in rural areas, this association was statistically not significant AOR = 1.65 (95% CI: 0.96-2.19), p = 0.05. Furthermore, unmarried TB patients have statistically significant more than thrice an increased odds of HIV co-infection compared to their married counterparts AOR = 3.75 (95% CI: 0.96-3.19), p = 0.04. Recommendations: There is urgent need for programmatic revision of ongoing TB intervention strategies, targeted capacity building for health personnel and intensified public awareness on Tuberculosis and Human Immune Deficiency Virus targeted interventions especially for males, unmarried people, urban dwellers, the sexually active, productive and reproductive age groups.