iarjmcrIARJMCRIARJMCR2709-3220https://doi.org/10.47310/iarjmcr.2022.v03i02.005Very High HDL: Boon or BaneArchieMadanSimardeepSodhiAasthaSehgalAnkineeduNannapaneniPrasadMedical Student, Lady Hardinge Medical College, IndiaMedical Student, Government Medical College Amritsar, IndiaThe buildup of fatty deposits within your artery walls is caused by excessive lipids, particularly LDL cholesterol, which reduces or blocks the flow of blood and oxygen to your heart. When total cholesterol levels are markedly elevated, the risk of cardiovascular disease increases significantly. LDL cholesterol is removed from the arteries by HDL cholesterol and returned to the liver for excretion. An abundance of HDL appears to guard against cardiovascular disease. We report this interesting case to emphasize that the patient with extremely high serum HDL and high total cholesterol has not developed any signs and symptoms of coronary heart disease. The patient is completely asymptomatic despite having extreme cholesterol deranged for 2 years.