iarjaccIARJACCIARJACC2709-1880https://doi.org/10.47310/iarjacc.2022.v03i02.026The Effectiveness of Intrathecal Bupivacaine-Fentanyl Vs. Levobupivacaine-Fentanyl in Sectio CaesareaRTHSupraptomoMuhammadDonyHermawanMuhammadDavid PerdanaPutraAuliyahTaniaAlkadrieDepartment of Anesthesiology and Intensive Therapy, Dr. Moewardi General Hospital, Surakarta, IndonesiaDepartment of Emergency, Muhammadiyah Babat Hospital, Lamongan, IndonesiaDepartment of Surgery, Muhammadiyah Babat Hospital, Lamongan, IndonesiaDepartment of Primary Health Care Lamongan, Lamongan, IndonesiaBackground: Spinal anesthesia is often administered in sectio caesarea. It is an easier and faster anesthetic technique to block the nervous system. Bupivacaine is the most common drug for spinal anesthesia in patients undergoing sectio caesarea. Levobupivacaine is an enantiomer of bupivacaine. In several studies, this agent is reported to have less cardiotoxic and neurotoxic effects and a shorter duration of the motor block than bupivacaine. This study aims to compare the effectiveness of intrathecal bupivacaine-fentanyl and levobupivacaine-fentanyl in patients undergoing sectio caesarea. Materials and Methods: This research involved 18-40-year-old patients who underwent elective sectio caesarea and cito with a gestational age of more than 37 weeks and the condition of the American Society of Anesthesiologists (ASA) class I and II. Thirty-two patients were divided into two groups (the group receiving bupivacaine 12.5 mg (2.5 mL) with fentanyl 25 mcg (0.5 mL) (Group BF) and the group receiving levobupivacaine 12.5 mg (2.5 mL) with fentanyl 25 mcg (0.5 mL) (LF Group)). The analgesic duration was recorded. Vital signs including blood pressure and pulse, neonatal side effects and patient side effects were recorded. Result: There was no statistically significant difference in analgesic duration between the two groups. The mean MAP was found to be lower in the BF group compared to the LF group. Hypotension and bradycardia were more common side effects in the BF group. There were no significant differences in neonatal effects. Conclusion: The combination of levobupivacaine 12.5 mg and fentanyl 25 mcg intrathecally can be a good alternative to the combination of bupivacaine 12.5 mg and fentanyl 25 mcg in sectio caesarea. Both are combinations for spinal anesthesia in sectio caesarea which are effective and have no side effects on neonates.