iarjaccIARJACCIARJACC2709-1880https://doi.org/10.47310/iarjacc.2021.v02i01.025A Clinical Comparative Study of Propofol and Ketamine Combination (Ketofol) Versus Either Drug Alone In Short Surgeries and ProceduresShrutiHiremathAssistant Professor, Department. Of Anaesthesia, Shivamogga Institute of Medical SciencesIntroduction: TIVA has many advantages over inhalational anaesthesia to name a few like its role in Day care surgeries, faster recovery rate, lesser hospital stay and so on. Various drugs have been tried in TIVA but no single drug have the ideal characteristics, hence various combinations of drugs are being used. One such drug combination is Ketofol (ketamine and propofol). Objective: To investigate ketofol as a suitable anaesthetic agent alternative to propofol, ketamine alone in short surgical procedures for onset, duration of anaesthesia, quality of analgesia, Haemodynamic and respiratory stability, adverse effects and recovery characteristics. Materials and methods: In this prospective comparative study, 3 group i.e, ketamine (k) group, propofol (p) group, ketofol (kp) group consisting 50 patients in each group undergoing short surgical procedures were studied. Each assigned group were premedicated and induced with ketamine 2mg/kg bodyweight in k group, propofol 2mg/kg bodyweight in p group and ketofol (ketamine 1mg/kg body wt+ propofol 1mg/kg body wt). The parameters like onset of action, duration, quality of analgesia, cardiorespiratory stability, adverse effects and recovery characters were studied. Results: We found significant difference p value <0.05 among k, p and kp groups. Kp (ketofol) group had better induction qualities, haemodynamic stability and lesser adverse effects. Conclusion: We concluded that ketofol (ketamine+propofol) combination is a better intravenous anaesthetic agent than propofol or ketamine alone in TIVA procedures.