iarjaccIARJACCIARJACC2709-1880https://doi.org/10.47310/iarjacc.2021.v02i01.06The Analgosedative Clinical Impacts of Morphine in Septic and Non-Septic Mechanically Ventilated Critically Ill PatientsQusaiMetlaqMigdadiMohamedAliAlhoraniEmadMutlaqMigdadiYazanKhaledZarerrRaafatAhmadAlramadnehJordanian Royal Medical Services, Amman, Jordan.Objective: Intravenous analgosedative agents are used widely in the critical care units to achieve the target Richmond agitation sedative scale in mechanically ventilated patients. Although commonly used analgosedatives are effective, many cause unwanted adverse effects, including delirium, constipation, and negative hemodynamic effects. However, there are limited comparison data on the safety and efficacy of morphine in both septic and non-septic mechanically ventillated critically ill patients. The purpose of this study is to determine whether continuous morphine infusion in septic mechanically ventilated critically ill patients will affect the total norepinephrine vasopressor rate and overall requirement, the hemodynamic parameters, the risk of opioid induced constipation, the ICU overall hospital length of stay (LOS), and the overall 28-day ICU mortality compared to the comparative cohort of non-septic patients. Method: A retrospective analysis was conducted in our adult ICU at King Hussein Medical Hospital (KHMH) for patients who were admitted via the emergency department (ED) or via other hospital wards between April 2018 and  April 2020. Patients will be excluded if they discharged or died before completed at least 1 week of ICU admission and if the patient is not ventilated. A chi square test will be conducted to evaluate the proportion of studied patients in both tested analgosedative based critically ill cohorts. An independent T-test will be conducted to compare the Mean±SD of the tested aforementioned outcomes. Result: The mean age of our studied critically ill patients was 58.94±10.37. 56 patients of the eligible sample were male while 22 were female (30.3%). The incidence of convulsive seizure and rate of prokinetic consumption were significantly lower in Group II vs Group I with number (%) of 14 (35.9%) vs19 (48.7%) and 37 (94.9%) vs 39 (100.0%). Critically ill patients on Morphine require higher Norepinephrine infusion rate in Sepsis status (11.22±1.70 mcg/min) vs Non-Sepsis status (6.17±0.76 mcg/min). Conclusion: Morphine infusion as analgosedative in septic mechanically ventilated critically ill patients has a higher risk of gastric residual volume elevation, convulsive seizure frequency, and require higher rate vasopressor to maintain a comparable hemodynamic target level. However, it did not appear to affect overall ICU length of stay or mortality.