srjmSRJMSRJM2788-9440https://doi.org/10.47310/srjm.2021.v01i01.013A Study of Pathophysiology of Homocysteine in Causing Acute Myocardial Infarction: A Study in a Rural Medical College of Himachal PradeshAmanSharmaShilpaSharmaHomocysteine, sulfhydryl group containing amino acid, is intermediate product during metabolism of the amino acids methionine and cysteine. Homocysteine is nonprotein amino acid which behaves as both a substrate and product of methionine. Homocysteine has key role in methylation cycle, within which a methyl group is transferred to a different substrate Formed homocysteine can be utilized in two ways: 1) homocysteine can be remethylated to methionine by catalytic activity of the enzyme N5, N10-methylenetetrahydrofolate reductase; 2) homocysteine can be converted to cysteine in a reaction that is catalyzed by Cystathionine β-Synthase (CBS). In this article, we tend to describe the pathophysiology of homocysteine in causing acute myocardial infarction.