iarjetIARJETIARJET2708-5163https://doi.org/10.47310/iarjet.2021.v02i01.012The Role of Ph Regulated Ionophore in Zinc Transport and the Control of Sars-Cov-2 Virus InvasionEvansChidiEgwimAlfredKaluOjiOluyemisiOmotayoOmonijeAdenikeTinukeBlanksonAdeolaMaryOmoniyiAmosNdarubuTsadoOdunayoSelimotAdedejiCentre for Genetic Engineering and Biotechnology,Federal University of Technology, P.M.B.65, Minna, NigeriaDepartment of Biochemistry, Federal University of Technology, P.M.B.65,Minna, NigeriaCovid 19 pandemic has been established to be caused by the novel SARS-CoV-2 and like most major viral outbreaks has posed enormous challenges of which different scientific and clinical approaches have been proposed. One approach to the inhibition and control of SARS-CoV-2 invasion is through pH regulated zinc ionophores. This work reviews current information on the background of the SARS-CoV2 pandemic, the key proteins that make up the peculiar structure of the virus and highlights the mechanism of invasion mainly from the binding of the S proteins of SARS-CoV-2 to the human angiotensin-converting enzyme 2 (ACE2). It explores the concept of pH regulated ionophores focusing on the mechanisms and regulation of zinc ionophores geared towards the inhibition and control of SARS-COV-2 invasion. The work then highlights the inhibitory mechanism of chloroquine on SARS-CoV-2 replication giving more depth to the proposition for its use in the treatment of the viral infection.